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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Hierarchical Editing Language for Macromolecules ： ウィキペディア英語版 Hierarchical Editing Language for Macromolecules The Hierarchical Editing Language for Macromolecules (HELM) is a method of describing complex biological molecules. It is a notation that is machine readable to render the composition and structure of peptides, proteins, oligonucleotides, and related small molecule linkers. HELM was developed by a consortium of pharmaceutical companies in what is known as the Pistoia Alliance. Development began in 2008. In 2012 the notation was published openly and for free.〔(【引用サイトリンク】 website= OpenHELM.org )〕 The HELM open source project can be found on GitHub.〔 ==HELM== The need for HELM became obvious as researchers began working on modeling and computational projects involving molecules and engineered biomolecules of this type. There was not a language to describe the entities in an accurate manner which described both the composition and the complex branching and structure common in these entity types.〔 Protein sequences can describe larger proteins and chemical language files such as mol files can describe simple peptides. However, the complexity of new research biomolecules makes describing large complex molecules difficult with chemical formats, and peptide formats arent flexible to describe non-natural amino acids and other chemistries.〔(【引用サイトリンク】title=HELM in ChEMBL )〕 In HELM, molecules are represented at a monomer level (instead of an atom level). Monomers are assigned short unique identifiers in internal HELM databases and can be represented by the identifier in strings. The approach is similar to that used in Simplified molecular-input line-entry system (SMILES). An exchangeable file format allows sharing of data between companies who have assigned different identifiers to monomers. In 2014 ChEMBL announced plans to adopt HELM by 2014.〔(【引用サイトリンク】title=The Pistoia Alliance and EMBL-EBI announce HELM collaboration for cheminformatics )〕 The informatics company Biovia developed a modified Molfile format called the Self-Contained Sequence Representation (SCSR) A standard which can incorporate individual attempts to solve the problem and be used universally and avoid proliferating standards is a goal of HELM.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Hierarchical Editing Language for Macromolecules」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.